Spyware/Virus Removal Utilities
The most effective way to remove spyware is to use a utility which automatically removes the offenders. Programs like Malwarebytes Antimalware and Spybot work really well for keeping the crapware at bay.
I also highly recommend
Microsoft Security Essentials for protecting your Windows 7 computer against the multitude of viruses out there. It works well, doesn't slow down your computer, and is FREE! For Windows 8, I have found Avast Antivirus to be great as well.